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Fexofenadine
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4-(1-hydroxy-4-(4-(hydroxydiphenylmethyl)-
1-piperidinyl)butyl)-α,α-dimethyl
-benzeneacetic acid
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CAS number
83799-24-0
| ATC code
R06AX26
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| Chemical formula
| C32H39NO4
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| Molecular weight
| 501.663
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| Bioavailability
| ?
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| Metabolism
| ?
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| Elimination half-life
| 14.4 hours
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| Excretion
| ?
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| Pregnancy category
| ?
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| Legal status
| Prescription only (US,UK)
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| Routes of administration
| ?
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Fexofenadine hydrochloride (brand names include Allegra® and Telfast®) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine, an antihistamine with potentially fatal contraindications.
History
Fexofenadine was developed by Hoechst Marion Roussel (now part of Aventis) and approved by the FDA in 1996. Since that time, it has achieved blockbuster drug status with global sales of $1.87B USD in 2004 (with $1.49B USD coming from the United States).
References
- Synthesis: J. Org. Chem. 1994, 59, 2620.
- Biological effects: Mol. Pharmacol. 1993, 44, 1240.
External links
- Fenofexadine (UK patient information leaflet)
| Antihistamines edit
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(Acrivastine)
(Astemizole)
(Azelastine)
(Brompheniramine)
(Carbinoxamine)
(Cetirizine)
(Chlorphenamine)
(Clemastine)
(Desloratadine)
(Dimenhydrinate)
(Diphenhydramine)
(Doxylamine)
(Loratadine)
(Fexofenadine)
(Meclizine)
(Promethazine)
(Triprolidine)
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